p16 Deficiency Protects Against Intervertebral Disc Degeneration by Inhibiting Oxidative Stress and Promoting Nucleus Pulposus Cell Proliferation

Mendeley Data2019-08-13 更新2026-04-09 收录

椎间盘退变机制

髓核细胞增殖

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Original, unprocessed data related to the paper.

创建时间：

2019-08-13

Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting the intrinsic circadian rhythm. Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting the intrinsic circadian rhythm

椎间盘退变机制

细胞生物力学

Nucleus pulposus cells were stretched using a FX-5000T Flexcell tension plus system (Flexcell International Corp., USA) with 18% elongation (0.2 Hz) for 24 h Overall design: To compare the effects of

NIAID Data Ecosystem90

Reactive Oxygen Species promote Pyroptosis of Nucleus Pulposus Cells in Modic changes with disc herniation based on smart-RNA sequencing

椎间盘退变机制

焦亡与氧化应激

We performed Smart-seq 2 and analyzed the differential expression of genes and pathways of Modic change to comparator group. Additionally, we detect the role of reactive oxygen species on pyroptosis o

NIAID Data Ecosystem40

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway

椎间盘退变机制

细胞凋亡通路

Evidence suggests that intervertebral disc degeneration (IVDD) can be induced by Propionibacterium acnes (P. acnes), although the underlying mechanisms are unclear. In this study, we analyzed the path

Figshare2019-04-02 更新20

Bushenhuoxue formula on Wnt/β-catenin signaling

椎间盘退变机制

中医干预

椎间盘退行性变（IDD）是腰痛的主要原因。本研究旨在探讨IL-1对IDD的影响及其与Wnt/β-连环蛋白信号传导的关系，并初步阐明中国传统配方布氏菌素配方（BSHXF）的影响。将30只C57BL/6小鼠随机分为正常对照组、椎间盘变性模型组、β-连环蛋白基因激活组、BSHXF+β-连环蛋白基因激活组和BSHXF+椎间盘变性模型组。8周后，进行影像学和组织病理学分析。观察椎间盘的病理变化，检测相关蛋白

Figshare2022-06-28 更新60

HO1 activates autophagy to protect intervertebral disc degeneration. HO1 activates autophagy to protect intervertebral disc degeneration

椎间盘退变机制

自噬保护机制

Intervertebral disc degeneration (IDD) is majorly resulted from disordered extracellular matrix (ECM) metabolism, including decreased anabolism and increased catabolism activities in the nucleus pulpo

NIAID Data Ecosystem40

p16 Deficiency Protects Against Intervertebral Disc Degeneration by Inhibiting Oxidative Stress and Promoting Nucleus Pulposus Cell Proliferation

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