Data for untargeted metabolomics of hemoglobin peptides of parasites with different plasmepsin copy numbers.

Two clones from the Cambodian RF7 parasite line with either one copy (B9) or three copies (D4) of plasmepsin II and III were used for metabolomic analysis, which includes the relative quantitation of short peptides [22]. High performance liquid chromatography-mass spectrometry (HPLC-MS)-based metabolomic analysis was run in both positive and negative mode, and a total of 35 putative endogenous hemoglobin derived peptides (dipeptides to 13-mers) based on m/z match were detected that could be mapped to either the alpha or beta chains of hemoglobin. The log2 fold changes of D4/B9 of all detected hemoglobin peptides are shown for three biological replicates each by positive and negative mode. The combined average log2 of D4/B9 and the -log10(p-value) of all putative peptides were plotted in S6A and S6B Fig. (XLSX)