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The Mpn1 exonuclease defines a novel spliceosomal snRNA decay pathway dependent on Rrp6 and Lsm2-8 complex

NIAID Data Ecosystem2026-03-08 收录

RNA降解通路

剪接体snRNA代谢

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA257728 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2014-08-07

翻译调控机制

RNA降解通路

We have identified mRNAs whose abundance or translational efficiency is regulated in nutrient-rich medium by the Scd6 or Dhh1 protein in either wild-type cells or dcp2∆ cells lacking the decapping enz

NIAID Data Ecosystem50

The fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [RIP-ChIP]

RNA降解通路

转录后调控

Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schiz

NIAID Data Ecosystem30

An RNA Endonuclease-Kinase Complex Required for Spreading and Epigenetic Inheritance of Heterochromatin

染色质表观遗传调控

RNA降解通路

The highly conserved multienzyme Rix1-containing complex (hereafter referred to as the rixosome), is required for ribosomal RNA (rRNA) processing and also localizes to heterochromatin in fission yeast

NIAID Data Ecosystem20

RNA-seq of hESC samples upon loss of UPF1.

细胞分化调控

RNA降解通路

Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental ce

NIAID Data Ecosystem40

Screening GeCKO lentiCRISPR knockout sgRNA library in human Fireworks HeLa cells to identify components and regulators of the human nonsense-mediated mRNA decay pathway.

CRISPRi筛选

RNA降解通路

We developed a method of in vivo amplification of NMD reporter fluorescence (Fireworks) that enables CRISPR-based forward genetic screening for NMD pathway defects in human cells. The Fireworks geneti

NIAID Data Ecosystem20

The Mpn1 exonuclease defines a novel spliceosomal snRNA decay pathway dependent on Rrp6 and Lsm2-8 complex

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