Inhibition of ketohexokinase C isoform impairs the development of PDAC tumors

ChEBI2023-07-07 更新2026-07-12 收录

胰腺导管腺癌

肿瘤代谢靶向

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-12746 数据链接链接失效反馈

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Inhibition of ketohexokinase C isoform impairs the development of PDAC tumors

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2023-07-07

Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia

肿瘤代谢靶向

抗凝血药物研发

Metabolic reprogramming of cancer cells is essential for tumorigenesis in which pyruvate kinase M2 (PKM2), the low activity isoform of pyruvate kinase, plays a critical role. Herein, we describe the i

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Discovery of Potent Small-Molecule SIRT6 Activators: Structure–Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity

SIRT6

胰腺导管腺癌

SIRT6 activation is thought to be a promising target for the treatment of many diseases, particularly cancer. Herein, we report the discovery of a series of new small-molecule SIRT6 activators. Struct

NIAID Data Ecosystem50

ena-DATASET-SLC-22-06-2017-12:04:40:959-248 - samples

癌细胞转录组

胰腺导管腺癌

RNAseq dataset of 34 samples (6 normals, 7 stroma-enriched, 21 malignant cells-enriched) from patients with resected pancreatic ductal carcinoma.EGA dataset EGAD00001003399

NIAID Data Ecosystem40

Additional file 3 of DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites

DNA甲基化

胰腺导管腺癌

Supplementary Material 3: Table S7. List of genes associated to differentially methylated CpGs mapping to promoters and enhancers in pairwise comparison: PAAD primary versus PAAD met.Liv., PAAD met.Li

DataCite Commons2025-10-29 更新70

Repeat RNA infection

胰腺导管腺癌

分子信号传导

Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) mimic viral-like responses with implications on tumor cell state and the response of the surrounding microenvironment. To

DataCite Commons2025-05-01 更新40

Inhibition of ketohexokinase C isoform impairs the development of PDAC tumors

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