HRGRN

HRGRN, a graph search-empowered integrative database of Arabidopsis signal transduction, metabolism, and gene regulatory networks. HRGRN utilizes the highly scalable graph database, Neo4j, to host large-scale of biological interactions among genes, proteins, compounds and small RNAs that were either validated experimentally or predicted computationally. The associated biological pathway information were also specially marked for the interactions that are involved in the pathway to facilitate the investigation of cross-talks between pathways. The outcomes are visualized with both rich text, figures and interactive network graphs on web pages.HRGRN是一款依托图搜索技术构建的拟南芥信号转导、代谢及基因调控网络整合数据库。该数据库采用高度可扩展的图数据库Neo4j，存储了基因、蛋白质、化合物与小RNA之间的大规模生物互作数据，所有互作数据均经过实验验证或计算预测所得。针对参与生物通路的互作数据，数据库还专门标记了其关联的通路信息，以助力研究者探究不同通路间的串扰关系。相关结果可通过富文本、图表及网页端交互式网络图实现可视化展示。

搜集汇总

背景与挑战

背景概述

HRGRN是一个整合数据库，专注于拟南芥的信号转导、代谢和基因调控网络，利用Neo4j图形数据库存储大规模实验验证或计算预测的生物相互作用（包括基因、蛋白质、化合物和小RNA）。该数据库特别标记了生物通路信息，便于研究通路间串扰，并提供富文本、图形和交互式网络图进行可视化。