TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex
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Polyubiquitinated RIPK1 binds to TAB2 resulting in the recruitment of the TAB2:TAK1 complex. The K63-linked ubiqitination on Lys377 of RIPK1 was shown to mediate the association of RIPK1 with the TAB2:TAK1 complex (Li H et al. 2006)
多泛素化RIPK1与TAB2结合,导致TAB2:TAK1复合体的募集。研究表明,RIPK1上的K63连接泛素化在Lys377位点上介导了RIPK1与TAB2:TAK1复合体的关联(Li H 等,2006年)
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