GUTSY Atlas

Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas ( https://gutsyatlas.serve.scilifelab.se/ ).人体肠道菌群可产生多种分子，其中部分可进入血液循环并影响机体健康。反之，膳食或药理学化合物在进入体循环前，亦可对肠道菌群产生调控作用。对这类互作关系进行表征，是解析肠道菌群对健康影响的关键步骤。本项横断面研究依托基于人群的瑞典心肺生物影像研究（Swedish CArdioPulmonary bioImage Study, SCAPIS）队列，纳入了8583名年龄介于50至64岁之间的受邀参与者，分别采用深度宏基因组测序（deep metagenomic sequencing）与超高效液相色谱-质谱联用技术（ultra-high-performance liquid chromatography linked to mass spectrometry），对参与者的肠道菌群与血浆代谢组进行精细化表征。本研究发现，肠道菌群可解释个体血浆代谢物高达58%的变异度；同时我们在在线关联图谱（https://gutsyatlas.serve.scilifelab.se/）中公布了997条肠道菌群α多样性与血浆代谢物的关联信息，以及546819条特定肠道宏基因组物种与血浆代谢物的关联信息。

搜集汇总

背景与挑战

背景概述

该数据集基于一项横断面研究，通过深度宏基因组测序和质谱分析，对8583名参与者的肠道微生物组和血浆代谢组进行了详细表征。研究发现肠道微生物组可解释高达58%的血浆代谢物个体差异，并提供了大量关于微生物多样性与代谢物关联的数据，相关结果已在线发布为交互式图谱。