Antigen-specific T Cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection

This dataset (Mycobacterium tuberculosis-specific T cells in recent and remote M.tb infection, and TB disease) contains M.tb-specific CD4 T cell function (IFN-g, TNF, IL-2), memory (CD45RA, CCR7) and activation (HLA-DR) profiles detected by flow cytometry or transcriptomics after CFP-10/ESAT-6 or M.tb lysate stimulation of PBMC from recent and persistent QFT+ individuals, and TB patients at diagnosis included in the manuscript "Antigen-specific T cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection". See paper for more details. Data sets included for each figure are indicated in the sheet name; Column names indicate: SubjectID, Group, Stimulation (stim) and the respective variable measured.

本数据集（近期及既往感染结核分枝杆菌特异性T细胞、结核病）收集了近期及持续阳性QFT+个体外周血单个核细胞（PBMC）在结核分枝杆菌胞壁蛋白10/早期分泌抗原6（CFP-10/ESAT-6）或结核分枝杆菌裂解物的刺激下，通过流式细胞术或转录组学检测到的结核分枝杆菌特异性CD4 T细胞功能（干扰素γ、肿瘤坏死因子α、白细胞介素2）、记忆（CD45RA、CCR7）及活化（HLA-DR）特征。相关数据集的详细信息可见于论文《抗原特异性T细胞活化区分近期与既往结核感染》。各图所包含的数据集名称以工作表命名标识；列名表示：受试者ID、分组、刺激（stim）以及相应测量的变量。