Venetoclax, alone or in combination with the BH3-mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice.

To determine the transcriptional changes that occur in CD4+ T cells from PLWH following ex vivo treatment with a pro-apoptotic inhibitor of Bcl-2. Comparisons were performed using bulk RNA-seq data from human CD4+ T cells isolated from PLWH, 24 hours post-treatment with a pro-apoptotic inhibitor of Bcl-2 at variopus concentrations. Comparative gene expression profiling analysis of human CD4+ T cell bulk RNA-seq data. Contrasts were made between cells treated with various concentrations of a pro-apoptotic inhibitor of Bcl-2 and cells treated with DMSO.