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Highly Enantioslective Synthesis of Multisubstituted Polyfunctional Dihydropyrrole via an Organocatalytic Tandem Michael/Cyclization Sequence

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Figshare2016-02-23 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Highly_Enantioslective_Synthesis_of_Multisubstituted_Polyfunctional_Dihydropyrrole_via_an_Organocatalytic_Tandem_Michael_Cyclization_Sequence/2625560
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A unique approach to asymmetric synthesis of various optically pure multisubstituted 2,3-dihydropyrroles catalyzed by a novel rosin-derived tertiary amine–thiourea via a tandem Michael/cyclization sequence with high yield (up to 97%) and good to excellent enantioselectivities (up to 97% ee) is present. This strategy provides an efficient and convenient method to access enantioenrich nitrogen heterocycles.
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2016-02-23
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