Regulation of intestinal epithelial turnover is a key component of villus maintenance in the intestine. The balance of cell turnover can be perturbed by various extrinsic factors including the cytokin
Given that SATB2 is expressed in differentiated colonic cells as well as the stem cells, we evaluated whether SATB2 might directly regulate the identity of the differentiated cells We administered a s
Using 3' droplet-based single-cell sequencing, we performed the transcriptional profiling of mouse large intestinal epithelial cells at the single-cell level. Overall design: For scRNA-seq of the mous
The function of m6A modification in colonic epithelial cells has been validated in our study that depletion of METTL14 in colonic epithelial cells triggers cell death. To further explore the biologica
