Releasing activity disengages cohesin’s Smc3/Scc1 interface in a process blocked by acetylation
收藏Alliance of Genome Resources2026-08-01 收录
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Sister chromatid cohesion conferred by entrapment of sister DNAs within a tripartite ring formed between cohesin’s Scc1, Smc1, and Smc3 subunits is generated during S and eventually destroyed at anaphase through cleavage of Scc1 by separase
由黏连蛋白（cohesin）的Scc1、Smc1与Smc3亚基之间形成的三分环包裹姐妹DNA所介导的姐妹染色单体黏连，于S期形成，并最终在分裂后期通过分离酶（separase）切割Scc1亚基而被解除
