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Releasing activity disengages cohesin’s Smc3/Scc1 interface in a process blocked by acetylation

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Sister chromatid cohesion conferred by entrapment of sister DNAs within a tripartite ring formed between cohesin’s Scc1, Smc1, and Smc3 subunits is generated during S and eventually destroyed at anaphase through cleavage of Scc1 by separase

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