RNA Atlas of Structure Probing

RASP (RNA Atlas of Structure Probing) is build from 161 deduplicated transcriptome-wide RNA secondary structures from datasets culled from 38 papers. RASP covers 18 species across animals, plants, bacteria, fungi, and also viruses, and categorizes 18 experimental methods including DMS-seq, SHAPE-Seq, SHAPE-MaP, and icSHAPE, etc. Specially, RASP curates the up-to-date datasets of several RNA secondary structure probing studies for the RNA genome of SARS-CoV-2. RASP also provides a user-friendly interface to query, browse, and visualize RNA structure profiles, offering a shortcut to accessing RNA secondary structures grounded in experimental data.RASP（RNA结构探测图谱集，全称RNA Atlas of Structure Probing）由来自38篇文献的161份去重全转录组RNA二级结构数据集构建而成。该数据集覆盖动物、植物、细菌、真菌与病毒共18个物种类群，收录了包括DMS-seq、SHAPE-Seq、SHAPE-MaP及icSHAPE等在内的18类实验方法。尤为特殊的是，RASP专门整理了针对SARS-CoV-2 RNA基因组的多项最新RNA二级结构探测研究数据集。此外，RASP还提供了便捷易用的用户交互界面，支持RNA结构特征的查询、浏览与可视化，为获取基于实验数据的RNA二级结构信息提供了快捷途径。

搜集汇总

背景与挑战

背景概述

RASP v2.0是一个全面的RNA结构探测数据库，整合了438个数据集，涵盖85篇文章、24个物种和39种实验方法，并首次融合了基于足迹和邻近连接的结构探测数据。该数据库提供多种在线分析功能，包括结构评分插补、RNA结构预测和RBP结合预测，以支持RNA功能机制的系统研究。