PU.1-driven gene regulation in HSPC under chronic inflammatory conditions
收藏NIAID Data Ecosystem2026-05-01 收录
官方服务：
资源简介：
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
应用场景：
创建时间：
2023-07-27
相关数据集
Convergence of Hypoxia and TGFβ Pathways on Cell Cycle Regulation in Human Hematopoietic Stem/Progenitor Cells
Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known about the specific mechanisms that are i
NIAID Data Ecosystem50
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia [amplicon-seq]
we uncover a key transcriptional network involving hundreds of genes that is required for HSC self-renewal. Overall design: MECOM impact on the hematopoietic stem cells
NIAID Data Ecosystem20
Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia (8-ATAC). Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia (8-ATAC)
Replication stress drives functional decline in HSCs and is a major driver of BM failure in Fanconi anemia (FA). At present, how HSCs respond and counteract replication stress remains largely unknown.
NIAID Data Ecosystem10
Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice
Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice
ChEBI2011-05-21 更新20
Maintenance of haematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition - STAT5 deficient HSPCs (LK). Maintenance of haematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition - STAT5 deficient HSPCs (LK)
Adult haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood and immune cells and must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highl
NIAID Data Ecosystem20
