Meta signature of third-trimester placental tissue mRNA expression.

Genes present in 3 or more complete signatures, or 3 or more signatures in total, are part of the meta-signature. For comparison, the number of times a gene is present in complete signatures below the significance threshold is shown in italics. Enquobahrie 2008, Kang 2011, Pang (combined) and Vaiman 2005 did not report the direction of differential expression (upregulation or downregulation).*Results were inconsistent among studies, the majority of studies reported the result presented here.–No consensus among studies: equal numbers of studies reported up- and downregulated expression in PE.