CDK1 phosphorylates condensin II subunit NCAPD3

Phosphorylation of the threonine residue T1415 of condensin II subunit NCAPD3 is required for chromosome condensation in prophase. In vivo, phosphorylation of NCAPD3 threonine residue T1415 is blocked when cells are treated with CDK1 inhibitors. In addition, it was shown that CDK1 in complex with cyclin B1 (CDK1:CCNB1) phosphorylates NCAPD3 at T1415 in vitro (Abe et al. 2011).

凝结蛋白II亚基NCAPD3中苏氨酸残基T1415的磷酸化对于有丝分裂前期染色体凝集至关重要。在体内实验中，当细胞被CDK1抑制剂处理后，NCAPD3中苏氨酸残基T1415的磷酸化被阻断。此外，已有研究表明，CDK1与周期蛋白B1（CDK1:CCNB1）形成的复合物在体外将NCAPD3在T1415位点磷酸化（Abe等人，2011年）。