Supplementary Material for: Cushing’s Syndrome in Adenocarcinoma of Lung Responding to Osilodrostat

Cushing syndrome (CS), secondary to paraneoplastic syndrome, is more commonly seen in small cell lung cancer (SCLC) but never before reported in EGFR-mutated adenocarcinoma of the lung. Here, we present a case of a patient whose symptoms of hypokalemia, hypertension and progressive abnormal glucose levels led to further workup that revealed ACTH-dependent hypercortisolism. Her cortisol levels dropped after one month of osilodrostat treatment while lung cancer was treated with osimertinib. The use of osilodrostat in paraneoplastic CS has been previously reported in only 3 patients.