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SpCas9 bound to 14-nucleotide complementary DNA substrate

NIAID Data Ecosystem2026-05-02 收录

CRISPR-Cas结构生物学

基因编辑机制

数据链接：

https://www.rcsb.org/structure/7Z4H 数据链接链接失效反馈

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SpCas9 bound to 14-nucleotide complementary DNA substrate

应用场景：

创建时间：

2025-07-09

基因编辑机制

细胞应激反应

DNA damage activates a robust transcriptional stress response, but much less is known about how DNA damage impacts translation. The advent of genome editing with Cas9 has intensified interest in under

NIAID Data Ecosystem90

SpCas9 with 17-bp R-loop containing 2 terminal mismatches (State I - pre-activation)

CRISPR-Cas结构生物学

基因编辑机制

SpCas9 with 17-bp R-loop containing 2 terminal mismatches (State I - pre-activation)

NIAID Data Ecosystem30

Crystal structure of SpyCas9 in complex with sgRNA and 17nt target DNA

CRISPR-Cas结构生物学

DNA复合物

Crystal structure of SpyCas9 in complex with sgRNA and 17nt target DNA

NIAID Data Ecosystem20

I-F3b Cascade-TniQ full R-loop complex

CRISPR-Cas结构生物学

蛋白质-核酸复合物结构

I-F3b Cascade-TniQ full R-loop complex

NIAID Data Ecosystem40

Cryo-EM structure of eSaCas9_NNG-guide RNA-target DNA complex in a translocation state

CRISPR-Cas9

基因编辑机制

Cryo-EM structure of eSaCas9_NNG-guide RNA-target DNA complex in a translocation state Descriptor: CRISPR-associated endonuclease Cas9, MAGNESIUM ION, Non-target DNA strand, ... Authors: Omura, S.N, N

Protein Data Bank Japan2026-04-29 更新20

SpCas9 bound to 14-nucleotide complementary DNA substrate

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