Latent Membrane Protein 1 and macrophage-derived TNFa synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma

To investigate the effect of TNFa and EBV on invadopodia formation, we treated the EBV-positive and -negative NPC43 cells seeded on gelatin with or without TNFa We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different groups Overall design: Comparative gene expression profiling analysis of RNA-seq data for -positive and -negative NPC43 EBV and the TNFa-treated counterpart