Nrf2-mediated fibroblast reprogramming drives cellular senescence by targeting the matrisome. ECM was isolated from WT and NRF2-/- mouse fibroblasts and analyzed by label-free quantification.
Lung squamous cell cancer (LUSC) is associated with very poor survival due to the lack of specific treatments. A common genetic alteration in LUSC involves mutations in NFE2L2 (also named NRF2) or its
Targeting the mitochondrial caseinolytic protease P (ClpP) is a potential novel strategy for treating cancer. However, little is known about the therapeutic effects of ClpP in lung squamous cell carci
The transcription factor NRF2 is closely connected to therapy resistancein tumors like lung and bladder cancer, where it is frequently constitutivelyactivated due to mutations in NRF2 or its inhibitor
Additional file 1. Figure S1. (a) TNFAIP2 mRNA expression between HNSCC and normal tissues from the TCGA. (b) Kaplan‒Meier survival curve of HNSCC patients with low versus high TNFAIP2 expression from
