Multi-omics study of DBD-a4 helix of EWS::FLI

NIAID Data Ecosystem2026-05-01 收录

尤文肉瘤分子机制

蛋白转录调控

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1048865 数据链接链接失效反馈

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资源简介：

Multi-omics study of DBD-a4 helix of EWS::FLI to understand the underlying mechanism of transcriptional regulation in Ewing sarcoma cell line: A673

创建时间：

2023-12-05

Identification of a novel FUS/ETV4 fusion and comparative analysis with other Ewing sarcoma fusion proteins [RNA-seq]

尤文肉瘤分子机制

转录组学分析

The purpose of this study was to determine the transcriptional regulatory similarities and differences in the FET/ETS translocations that have been identified as drivers of Ewing sarcoma. Overall desi

NIAID Data Ecosystem50

Supplementary Table S6 from KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma

尤文肉瘤分子机制

表观遗传调控

Excel file showing DEG and downregulated direct targets upon KDM6A or KDM6B knockout.

Figshare2025-11-14 更新40

Transcriptional constraint of EWS/FLI by an ETS transcription factor promotes Ewing sarcoma growth [RNA-seq]

尤文肉瘤分子机制

RNA-seq转录组学

Pediatric cancers frequently harbor sentinel mutations involving transcription factors (TFs) that dysregulate normal development. A recurrent mechanism involves the ability of mutant TFs to co-opt cel

NIAID Data Ecosystem20

EWS::FLI cooperatively binds at GGAA microsatellites via DBD-a4 helix in TTC-466 [H3K27ac_CnT]

尤文肉瘤分子机制

转录组调控

Multi-omics study of DBD-a4 helix of EWS::FLI to understand the underlying mechanism of transcriptional regulation in Ewing sarcoma cell line: TTC-466 In TTC-466 cells, we knock-down endogenous EWSR1:

NIAID Data Ecosystem40

Table 2_Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer’s disease stages.xlsx

阿尔茨海默病机制

蛋白转录调控

IntroductionRecent research revealed that Tau plays critical roles in various neuronal functions. We previously demonstrated that destabilization and nuclear delocalization of Tau alter the expression

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Multi-omics study of DBD-a4 helix of EWS::FLI

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