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Identification of novel human intermediate progenitor genes in cortical development

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1213291
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To identify the transcriptional signature of human IPCs (hIPCs), we isolated TBR2-positive IPCs from developing human neocortex. We utilized an antibody to mark intranuclear TBR2 in single-nucleus suspensions purified from developing human neocortex procured at the peak of neurogenesis at gestational weeks (GW)14-17, and sorted the TBR2+ nuclei (considered hIPC derived) from the TBR2- nuclei (considered non-hIPC derived). RNA-seq was performed to determine the expression profiles of hIPC-enriched genes.
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2025-01-21
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