Unique combinations of amino acid residues at 13 important substrate recognition sites.

From the woodrat CYP2B dataset, amino acid residues at 13 sites shown to be important for CYP2B function in model systems [57], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70]. Letters refer to unique combinations of these 13 important residues as they are represented across branches and individual sequences on the CYP2B phylogeny (Figure 3). Columns with bolded amino acid abbreviations indicate residues that vary across the dataset. Corresponding human and rat CYP2B isoform residues are included for comparison.