STAT3-dependent MIR-21 gene expression

Expression of MIR21 is repressed by STAT3 binding to its promoter. STAT2-dependent repression of miR-21 in turn leads to upregulation of DNMT1, a miR-21 target. Downstream of NPM1-ALK, DNMT1 contributes to repression of IL2RG gene expression by methylating the IL2RG promoter (Zhang et al, 2011).

MIR21的表达受STAT3与启动子结合的抑制。STAT2依赖性的miR-21抑制进而导致DNMT1（miR-21靶标）的上调。在NPM1-ALK下游，DNMT1通过甲基化IL2RG启动子，进而参与抑制IL2RG基因表达的调控（张等，2011年）。