Receiver Operating Characteristic Curve Areas for CDR 0 vs <0 Comparison.

ROC analyses of ‘validation’ cohort ELISA data were performed for each biomarker to distinguish CDR>0 from CDR 0 (“earlier diagnosis”). A stepwise logistic regression model, applied to identify a complementary combination of these biomarkers that would optimize accuracy (maximize area under the curve [AUC]) without including additional non-contributory biomarkers, accepted tau, YKL-40 and NrCAM and yielded an AUC of 0.8955 (“Logistic Regression,” lowest row).