Mutation analysis of the GTPase domain of GGAP2 in prostate cancer.

The GTPase domain was cloned from cDNAs from prostate cancer (>70% cancer) or benign peripheral zone tissues and sequenced. A total of 23 cancers and 12 benign tissue samples were analyzed. The number of clones is indicated as is the number and percentage of clones with missense mutations. For each individual tissue the missense mutations are shown using the format: normal amino acid/amino acid number in GGAP2/mutant amino acid. Only tissues with missense mutations are shown.