Supplementary materials: Acute effects of resistance exercise with blood flow restriction on cardiovascular response: a meta-analysis

These are peer-reviewed supplementary materials for the article 'Acute effects of resistance exercise with blood flow restriction on cardiovascular response: a meta-analysis' published in the Journal of Comparative Effectiveness Research.Appendix 1: Search strategiesAppendix 2: Funnel plot analysisAppendix 3: Table 1. Methodological quality of eligible studies, PEDRo scale.Appendix 4: Assessment of the quality of evidence through the grade systemAppendix 5: Exploratory analysis of the BFR and resistance trainingAim: To compare the acute effects of low-load resistance training associated with blood flow restriction (LLRT-BFR) with low-load resistance training (LLRT) and high-load resistance training (HLRT) on cardiovascular outcomes in healthy individuals. Methods: This review was registered and the studies were selected using seven databases. Randomized controlled clinical trials were included that evaluated LLRT-BFR compared with LLRT and HLRT in young individuals for the cardiovascular outcomes. Results: 19 studies were included. In the comparison of LLRT-BFR with HLRT, there were significant differences for cardiac output and heart rate – with reduced values and in favor of LLRT-BFR. Conclusion: There are no greater acute effects of the addition of blood flow restriction, with the exception of the reduction in cardiac output and heart rate for LLRT-BFR compared with HLRT.