Associations of exercise habit, estradiol, and skeletal muscle mass with bone mineral density in women aged 50-59 years: a cross-sectional study stratified according to menopausal status

This dataset contains de-identified individual-level data used in the cross-sectional study entitled “Associations of exercise habit, estradiol, and skeletal muscle mass with bone mineral density in women aged 50–59 years: a cross-sectional study stratified according to menopausal status.” The study investigated differences in lumbar spine and femoral neck bone mineral density (BMD) according to menopausal status and examined whether exercise habit was associated with BMD in postmenopausal women. Participants were women aged 50–59 years who completed questionnaire assessments, body composition measurements, dual-energy X-ray absorptiometry (DXA), and blood sampling. Final analyses included 78 participants: 19 premenopausal women and 59 postmenopausal women. The postmenopausal women were further classified into a menopause-active group (MA; n = 31) and a menopause-non-active group (MN; n = 28) according to exercise habit, defined as exercise for at least 30 minutes per session, at least twice per week, maintained for more than 1 year.
The dataset includes participant ID and group classification, demographic and body composition variables (age, years since menopause, height, weight, skeletal muscle mass, body fat amount, body mass index, skeletal muscle percentage, and waist-to-hip ratio), DXA-derived bone outcomes (lumbar spine BMD, lumbar spine T-score, lumbar spine Z-score, femoral neck BMD, femoral neck T-score, and femoral neck Z-score), and blood biomarkers (serum calcium, bone-specific alkaline phosphatase, TRACP-5b, estradiol, total P1NP, and 25-hydroxyvitamin D). The dataset also contains the VDDQ-J score. For premenopausal participants, “years since menopause” is not applicable and is recorded as a placeholder value. The data were used for between-group comparisons and multivariable regression analyses examining factors associated with lumbar spine and femoral neck BMD. This dataset supports the findings that skeletal muscle mass and estradiol were independently associated with BMD, and that exercise habit was independently associated with femoral neck BMD among postmenopausal women.