Profiling of the reprogramome and quantification of fibroblast reprogramming to pluripotency
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Recognized as being intensive and extensive, the degree of pluripotency reprogramming, however, has not been quantitatively determined before. Here we report a novel concept, reprogramome. Fine mapping of reprogramome indicates that the amount of reprogramming genes is equivalent to 57% of the fibroblast transcriptome, with a large erasome and activatome.We further developed a simple mathematical model to quantitate reprogramming. The total reprogramming is 26,032 LFC units (log2-transformed fold changes). Such quantification indicates that reprogramming in WNT pathways represents 2% of the total reprogramming; and reprogramming in genes involved in cellular morphogenesis represents 7.7% of the total reprogramming.In summary, we have developed a novel concept, reprogramome, for fine profiling of the reprogramming, as well as a mathematical model for accurate quantification of the reprogramming.
提供机构：
University of Alabama at Birmingham
创建时间：
2022-02-20
