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Targeted sequencing of ~450 cancer genes in 38 pairs of cancer cell lines and their Cas9-expressing derivatives
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创建时间：
2020-04-01
相关数据集
Improved inference of site-specific positive selection under a generalized parametric codon model when there are multinucleotide mutations and multiple nonsynonymous rates
Background: An excess of nonsynonymous substitutions, over neutrality, is considered evidence of positive Darwinian selection. Inference for proteins often relies on estimation of the nonsynonymous
NIAID Data Ecosystem100
Macrophages from Rosa26-integrated Cas9-expressing C57BL/6 mice have a putative TRIF-mediated defect in the TLR-3/4 signaling
In this study, we report that the TLR4 ligand, LPS, and TLR3 ligand polyinosinic:polycytidylic acid failed to activate IRF3 or STAT1 in bone marrowâderived macrophages (BMMs) isolated from two indep
NIAID Data Ecosystem60
Generation and Sequence Confirmation of a Slc13a5 KO Mouse Model
A _Slc13a5_^Arg337*^ mouse model homologous to human _SLC13A5_ mutation (p.Arg333*) was generated in C57BL/6J background using CRISPR/Cas9. The coding exons and exon/intron borders of the F2 generatio
DataCite Commons2020-07-16 更新40
Lysoplex: An efficient toolkit to detect DNA sequence variations in the autophagy-lysosomal pathway
The autophagy-lysosomal pathway (ALP) regulates cell homeostasis and plays a crucial role in human diseases, such as lysosomal storage disorders (LSDs) and common neurodegenerative diseases. Therefore
Taylor & Francis Group2016-01-19 更新70
Additional file 1: Table S1. of Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort
DSD gene variants. Each variant found in a diagnostic gene (after the filtering and curation process) is shown. In some cases where the gene is inherited in an autosomal recessive manner, two variants
Figshare2016-12-14 更新40
