NGF:p75NTR complex binds to NRAGE

NRAGE (neurotrophin receptor-interacting MAGE homolog), a member of the MAGE family of proteins, is a cytoplasmic protein that mediates neurotrophin-induced cell death. NRAGE binding is stimulated following NGF (or proNGF) binding to p75NTR. Some studies indicate that NRAGE expression is limited to proliferative neural populations, whereas others indicate its presence in differentiated neurons in hippocampus. Another MAGE protein, Necdin, was reported to interact with p75NTR and affect cell death.

NRAGE（神经生长因子受体相互作用MAGE同源蛋白），MAGE蛋白家族的一员，是一种介导神经生长因子诱导的细胞死亡的细胞质蛋白。NRAGE的结合在NGF（或前NGF）与p75NTR结合后得到增强。一些研究表明，NRAGE的表达局限于增殖的神经细胞群体，而另一些研究表明其在海马体中分化的神经元中存在。另一MAGE蛋白Necdin据报道与p75NTR相互作用并影响细胞死亡。