Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor
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Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor Descriptor: 5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin-3(2H)-one, RNA-directed RNA polymerase Authors: Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. Deposit date: 2007-12-23 Release date: 2008-12-23 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
创建时间：
2007-12-23
