No diagnostic utility of antibody patterns against <i>Klebsiella pneumoniae</i> capsular serotypes in patients with axial spondyloarthritis vs. patients with non-specific low back pain: a cross-sectional study

<b>Objectives</b>: To investigate whether antibody response patterns against <i>Klebsiella pneumoniae</i> capsular serotypes can discriminate patients with axial spondyloarthritis (axSpA) from patients with non-specific low back pain (LBP). <b>Method</b>: Immunoglobulin (Ig)G and IgA antibodies against <i>K. pneumoniae</i> capsular serotypes K2, K26, K36, and K50 were measured, and antibody seropositivity compared between groups and analysed for patient correlation in five different groups: (a) 96 patients fulfilling the Assessment of SpondyloArthritis International Society (ASAS) classification criteria for axSpA; (b) 38 patients with either a positive magnetic resonance imaging (MRI) scan as defined by ASAS or a positive human leucocyte antigen (HLA)-B27 status plus one clinical SpA feature, characterized as ‘non-axSpA’; (c) 82 non-specific LBP patients; (d) 40 healthy blood donors and (e) 43 patients with diagnosed ankylosing spondylitis (AS) served as the negative and positive control groups. <b>Results</b>: There was no difference in IgG and IgA seropositivity against all serotypes between the axSpA, non-axSpA, and LBP groups. No significant correlations were found between anti-<i>Klebsiella</i> antibodies and age, gender, HLA-B27, or high-sensitivity C-reactive protein (hsCRP). IgG seropositivity against K50 was more frequent in AS (25.6%) than in axSpA (13.5%, p <b>Conclusions</b>: The antibody patterns against <i>K. pneumoniae</i> serotypes K2, K26, K36, and K50 did not discriminate between early axSpA and non-specific LBP.**研究目标**：探讨针对肺炎克雷伯菌（Klebsiella pneumoniae）荚膜血清型的抗体应答模式，能否将轴性脊柱关节炎（axial spondyloarthritis, axSpA）患者与非特异性腰痛（non-specific low back pain, LBP）患者区分开来。 **研究方法**：本研究检测了针对肺炎克雷伯菌荚膜血清型K2、K26、K36及K50的免疫球蛋白G（IgG）与免疫球蛋白A（IgA）抗体，并在以下5组人群中比较各组间的抗体血清阳性率、分析其与患者相关指标的相关性：(a) 96名符合国际脊柱关节炎评估协会（Assessment of SpondyloArthritis International Society, ASAS）轴性脊柱关节炎分类标准的患者；(b) 38名满足ASAS定义的磁共振成像（magnetic resonance imaging, MRI）阳性，或人类白细胞抗原（human leucocyte antigen, HLA）-B27阳性且伴1项临床脊柱关节炎特征的患者，归类为“非轴性脊柱关节炎（non-axSpA）”；(c) 82名非特异性腰痛患者；(d) 40名健康献血者；(e) 43名确诊强直性脊柱炎（ankylosing spondylitis, AS）的患者，作为阴性与阳性对照队列。 **研究结果**：轴性脊柱关节炎、非轴性脊柱关节炎与腰痛组之间，针对所有血清型的IgG与IgA血清阳性率均无显著差异。抗肺炎克雷伯菌抗体与年龄、性别、HLA-B27或高敏C反应蛋白（hsCRP）均未发现显著相关性。针对K50的IgG血清阳性率在强直性脊柱炎组（25.6%）中的检出率高于轴性脊柱关节炎组（13.5%，P<）。 **研究结论**：针对肺炎克雷伯菌血清型K2、K26、K36及K50的抗体谱，无法区分早期轴性脊柱关节炎与非特异性腰痛患者。

搜集汇总

背景与挑战

背景概述

该数据集基于一项横断面研究，旨在评估抗肺炎克雷伯菌荚膜血清型（K2、K26、K36、K50）的抗体模式在区分轴性脊柱关节炎（axSpA）患者与非特异性下背痛（LBP）患者中的诊断效用。研究结果表明，IgG和IgA抗体阳性率在axSpA、非axSpA和LBP组间无显著差异，且抗体模式与临床参数无相关性，因此结论为这些抗体模式不能有效区分早期axSpA和非特异性LBP。