DNA Damage Induces a Secretory Program in the Quiescent Tumor Microenvironment that Promotes Adverse Prostate Cancer Phenotypes. Homo sapiens

Benign quiescent cells in the tumor microenvironment respond to genotoxic stress by inducing a secretory program capable of promoting therapy resistance. Developing approaches to suppress the secretory program may improve treatment responses. Overall design: Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile proliferating, quiescent, and ionizing-radiation treated PSC27 human primary prostate fibroblast cells. RNA was amplified prior to hybridization against a common reference pool of prostate tumor cell lines.