Spatial-Mux-seq: Multiplexed spatial mapping of chromatin features, transcriptome, and proteins at tissue scale

We present a multi-modal spatial technology that allows simultaneous profiling of four different modalities, including multi epigenomic modalities (any combination of two histone modifications and open chromatin at the same time), whole transcriptome, and a panel of proteins at tissue scale and cellular level in a spatially resolved manner. Spatially resolved multiple modalities sequencing in mouse tissues.