A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon ?

To understand the immunomodulation roles of complement C1q-like protein 3 (IsC1ql3), we utilized RNA sequencing (RNA-seq) to investigate the effect of IsC1ql3 on the murine transcriptome. Overall design: We compared the transcriptome of murine splenocytes stimulated by the Lyme disease agent Borrelia burgdorferi, with or without IsC1ql3, for 6 hours.