Transcriptomic Analysis of Molecular Mechanisms Underlying Masseter Muscle Disuse Atrophy in mice

Description:This study utilized a unilateral molar extraction model in C57BL/6J mice to systematically investigate the molecular mechanisms of masseter muscle disuse atrophy. Transcriptomic analysis (RNA sequencing) was performed on masseter muscle samples collected from both normal mice and mice subjected to 8 weeks of disuse atrophy. The results revealed significant alterations in genes associated with muscle remodeling, cell signaling, and inflammation, highlighting potential regulatory pathways and key factors. The dataset includes raw RNA sequencing data (FASTQ format) and normalized gene expression values (FPKM format), providing essential resources for understanding the molecular mechanisms of disuse atrophy and identifying potential therapeutic targets for muscle function loss.Keywords:Masseter muscle, disuse atrophy, transcriptomics, gene expression regulation, muscle remodelingData Type:RNA sequencing data (Illumina platform)Sample Information:Species: Mus musculus (C57BL/6J)Experimental Groups: Normal (control) and disuse atrophy group (8 weeks post-extraction)Research Background:Disuse atrophy is a condition characterized by the loss of muscle mass and function due to reduced muscle activity. While the mechanisms of disuse atrophy have been extensively studied in limb skeletal muscles, the masseter muscle remains underexplored. This study employs transcriptomic approaches to uncover the regulatory networks underlying disuse atrophy in the masseter muscle, providing valuable insights into its pathogenesis and potential therapeutic strategies.