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Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing

NIAID Data Ecosystem2026-03-12 收录

Cas9蛋白

病毒样颗粒

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP307110 数据链接链接失效反馈

官方服务：

资源简介：

Develop virus-like particles for spCas9 RNP delivery

应用场景：

创建时间：

2021-02-21

Cas9蛋白

基因组编辑精准性

The CRISPR-Cas9 system provides a versatile toolkit for genome engineering that can introduce various DNA lesions at specific genomic locations. However, a better understanding of the nature of these

NIAID Data Ecosystem60

DNA-Free Recombinant SV40 Capsids Protect Mice from Acute Renal Failure by Inducing Stress Response, Survival Pathway and Apoptotic Arrest

急性肾损伤

病毒样颗粒

Viruses induce signaling and host defense during infection. Employing these natural trigger mechanisms to combat organ or tissue failure is hampered by harmful effects of most viruses. Here we demonst

NIAID Data Ecosystem40

RNA-free helical (h8.6) virus-like particle composed of JGMV coat protein

病毒样颗粒

植物病毒蛋白组装

RNA-free helical (h8.6) virus-like particle composed of JGMV coat protein Descriptor: Genome polyprotein Authors: Koritnik, N, Kezar, A, Podobnik, M. Deposit date: 2025-05-20 Release date: 2026-01-21

Protein Data Bank Japan2026-02-25 更新30

DataSheet3_A novel C-terminal modification method enhanced the yield of human papillomavirus L1 or chimeric L1-L2 virus-like particles in the baculovirus system.docx

HPV疫苗

病毒样颗粒

Human papillomavirus (HPV) major capsid protein L1 virus-like particles (VLPs) produced in the baculovirus system showed excellent safety and immunogenicity, but the relatively high production cost st

NIAID Data Ecosystem40

Developing small Cas9 hybrids using molecular modeling

Cas9蛋白

分子建模设计

The RNA-guided CRISPR-Cas9 from Streptococcus pyogenes is the best characterized enzyme for gene editing. Its large size, however, precludes it from being packaged together with its single guide (sg)R

NIAID Data Ecosystem30

Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing

资源简介：

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