Hub and bottlenecks present in the SteinerNet A549 and SW900 networks.

Node color refers to the networks color code: green, proteins upregulated (fold-regulation > 2); red, proteins downregulated (fold-regulation > -2); yellow, unaltered proteins; violet, cell line-specific proteins obtained in the study; grey, proteins obtained from HIPPIE database. A threshold degree of >10 and betweenness centrality of >0.3 were used to retrieve the hubs and bottlenecks. Light green color in degree and betweenness centrality represents high values. Light orange color represents the nodes that are hub-bottlenecks.