Transcriptional differences between controls (group 1) and subtypes of CDV leukoencephalitis (group 2–4).

†Multigroup test followed by independent pairwise post-hoc comparisons employing LIMMA with a false discovery rate (Benjamini and Hochberg) filter of q≤0.05, and a fold change filter of ≥2.0 or ≤ −2.0.‡Gene as defined by the DAVID knowledgebase. Multiple probe sets may match to a single gene, and probe sets may be unassigned (expressed sequence tags).§Biological modules associated with the DEG as detected by the DAVID functional annotation clustering algorithm using orthologous mouse genes.DEGs = differentially expressed genes; DEPs = differentially expressed probe sets; ES = enrichment score; group 1 = control dogs, group 2 = acute CDV leukoencephalitis, group 3 = subacute CDV leukoencephalitis, group 4 = chronic CDV leukoencephalitis.