Cathepsin B1 from Schistosoma mansoni in complex with gallinamide analog 1

Cathepsin B1 from Schistosoma mansoni in complex with gallinamide analog 1 Descriptor: Cathepsin B-like peptidase (C01 family), SODIUM ION, [(2~{S})-1-[[(2~{S})-1-[[(2~{S})-5-[(2~{S})-3-methoxy-2-(2-methylpropyl)-5-oxidanylidene-2~{H}-pyrrol-1-yl]-5-oxidanylidene-pentan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl] (2~{S},3~{S})-2-(dimethylamino)-3-methyl-pentanoate Authors: Rubesova, P, Brynda, J, Gerwick, W.H, Mares, M. Deposit date: 2023-01-27 Release date: 2024-02-07 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis. Acs Infect Dis., 10, 2024