overexpression

overexpression of CIRP and its mechanisms research
Cold inducible RNA-binding protein (CIRP) is a glycine-rich RNA-binding protein with an RNA recognition motif and a carboxyl-terminal domain. CIRP initially localized in the nucleus, under some stresses, especially cold stress, it can translocate to the cytoplasm and bind the 3’ regions of the target mRNA with its RNA-recognition motif, and then exerts an effect on regulating gene expression. CIRP expression in the brain is increased significantly under cold stress, and the upregulation of CIRP plays an important role on triggering the animal hibernation. These findings inspired the idea that highly expressed CIRP may induce neuroprotection. Our previous studies demonstrated that CIRP can inhibit neuron apoptosis, overexpressed CIRP under hypoxia can restore the proliferation of neuronal stem cells, suggesting a neuroprotective role of CIRP.