Crystal structure of NLRP3 in complex with inhibitor NP3-742
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Crystal structure of NLRP3 in complex with inhibitor NP3-742 Descriptor: 5-methyl-~{N}-[(3~{R})-1-methylpiperidin-3-yl]-6-(2-methyl-1~{H}-pyrrolo[2,3-b]pyridin-6-yl)pyridazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... Authors: Srinivas, H. Deposit date: 2025-08-19 Release date: 2025-10-22 Last modified: 2025-11-26 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement. J.Med.Chem., 68, 2025
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2025-08-19
