Prnp

Enables several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and cupric ion binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein phosphorylation; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of apoptotic process; regulation of potassium ion transmembrane transport; and response to oxidative stress. Located in several cellular components, including Golgi apparatus; membrane raft; and terminal bouton. Colocalizes with dendrite. Is expressed in several structures, including cardiovascular system; genitourinary system; nervous system; sensory organ; and tooth. Used to study Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; and fatal familial insomnia. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (prion protein (Kanno blood group)). [provided by Alliance of Genome Resources, Nov 2024]

该数据集具备多种功能，包括与淀粉样蛋白-β的结合活性；天冬氨酸型内肽酶抑制活性；以及与铜离子的结合活性。参与多种生物学过程，包括对大分子代谢过程的负调控；对蛋白质磷酸化的正调控；以及对信号转导的调控。在包括细胞凋亡过程的负调控、钾离子跨膜转运的调控以及对氧化应激的反应等过程中发挥上游作用或位于其中。存在于多个细胞成分中，如高尔基体；膜筏；以及突触末端。与树突共定位。在心血管系统；泌尿生殖系统；神经系统；感觉器官；以及牙齿等多种结构中表达。用于研究克雅氏病；格斯特曼-斯特劳斯勒-舍伊纳综合征；致死性家族失眠症。该基因的人类直系同源基因与克雅氏病；格斯特曼-斯特劳斯勒-舍伊纳综合征；亨廷顿病样1；致死性家族失眠症；以及库鲁病有关。与人类PRNP（Kanno血型）蛋白同源。[由基因组资源联盟提供，2024年11月]