BIC, Breast Cancer Information Core; IARC, International Agency for Research on Cancer; HR, hormonal receptor status; (a), mutation identified in Brazilian patients reported by others; ND: not determi
PALB2 is an important BRCAx candidate for familial breast cancers (FBC). PALB2 pathogenic variants (PVs) may not to conform to “two hit” paradigm. However, a recent study demonstrates that in the majo