<b>The Role of Gut Microbiota and Plasma Metabolites in Osteoporosis: Insights from Mendelian Randomization Analysis</b>

Table 1 Instrumental variables of gut microbiota after clumping and exclusion of week IVsTable 2 Instrumental variables of plasma metabolites after clumping and exclusion of week IVsTable 3 Causal effects of gut microtiota on osteoporosis (Forward MR analysis)Table 4 Causal effects of osteoporosis on indentified gut microbiota (Reverse MR analysis)Table 5 Genetic correlation between identified gut microbiota and osteoporosis (LDSC analysis)Table 6 Causal assciations between plasma metabolites and osteoporosis (Associations only with PIVW less than 0.05 and consistent with all sensitivity analysis were listed)Table 7 Causal assciations between identified gut microbiota and 91 plasma metabolitesTable 8 Mediantion analysis between gut microbiota, plasma metabolites, and osteoporosis