Iodine-Catalyzed Chemoselective Hydroamination Reaction Using 5‑Mercaptotetrazoles Derivatives

Metal-free
chemoselective hydroamination of styrene derivatives
has been achieved with high chemoselectivity over sulfenylation of
1H-tetrazole-5-thiol using a catalytic amount of
iodine. The scope of this methodology has been extended for the hydroamination
of α-substituted styrene derivatives. This reaction involves
a single-step C–N-bond formation under atom economical process.
This eco-friendly method uses readily available and inexpensive iodine
in a catalytic amount.