X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in complex with GRL-142
收藏Protein Data Bank Japan2023-10-11 更新2026-03-21 收录
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X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in complex with GRL-142 Descriptor: (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, 1,2-ETHANEDIOL, Protease Authors: Bulut, H, Hattori, S.I, Aoki-Ogata, H, Hayashi, H, Aoki, M, Ghosh, A.K, Mitsuya, H. Deposit date: 2019-04-03 Release date: 2020-04-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Novel HIV-1 protease inhibitors, GRL-142 and its analogs, markedly adapt to the structural plasticity of HIV-1 protease and exerts extreme potency with high genetic barrier To Be Published
创建时间：
2019-04-03
