RNA-seq of mouse 1-cell embryos
收藏Alliance of Genome Resources2026-08-01 收录
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Initiation of zygotic transcription in mammals is poorly understood. In mice, zygotic transcription is first detected shortly after pronucleus formation in 1-cell embryos but the identity of the transcribed loci and mechanisms regulating their expression are not known. Using total RNA-seq we find that transcription in 1-cell embryos is highly promiscuous such that intergenic regions are extensively expressed and thousands of genes are transcribed at relatively low levels.
