Citrobacter rodentium strain:ATCC 51459 (DBS100) Transcriptome or Gene expression

Citrobacter rodentium (Cr) is a mouse pathogen that mimics many aspects of enteropathogenic Escherichia coli infections including producing attaching and effacing (A/E) lesions. Host-adapted (HA) Cr cells that are shed at the peak of infection have been reported to be hyperinfective. The exact mechanism underlying this phenomenon has remained elusive since the pathogen loses its HA ‘status’ immediately upon sub-culturing in laboratory media. We sequenced the entire transcriptome of Cr isolated from the feces of infected mice and from media grown Cr, and looked for differentially expressed genes. These results demonstrate that host-adapted Cr has a unique transcriptome that is associated with increased host transmission.